Exploring Rejuran: Benefits and Results Injected vs. Topical Application

Achieving radiant, youthful skin is a goal many skincare lovers pursue, especially those chasing the coveted glass skin look popularized by Korean skincare routines. One treatment gaining attention in medspas, especially in NYC, is Rejuran. Known for its unique ingredient, PDRN (polydeoxyribonucleotide) derived from salmon DNA, Rejuran offers skin healing and rejuvenation with minimal downtime. This post explores what Rejuran is, its benefits, and compares the effects of direct injections versus topical application combined with microneedling and laser treatments.

What Is Rejuran and How Does It Work?

Rejuran is a skin treatment that uses Rejuran PDRN, a purified DNA fragment extracted from salmon. This ingredient supports skin repair by stimulating cell regeneration, improving elasticity, and reducing inflammation. The treatment originated in Korea and has become a viral sensation in the world of Korean facials and skincare.

Unlike traditional fillers or Wrinkle Relaxers, Rejuran focuses on healing and strengthening the skin from within as a biostimulator. It promotes collagen production and enhances the skin’s natural barrier, which helps reduce fine lines, scars, and uneven texture.

Benefits of Rejuran Treatments

Rejuran offers several benefits that make it popular among skincare enthusiasts:

• Improves skin texture and elasticity

• Reduces fine lines and wrinkles

• Enhances hydration and skin barrier function

• Minimizes acne scars and pigmentation

• Promotes a natural glow and youthful appearance

  
  

Many clients report smoother, plumper skin with a noticeable glow after a series of treatments. The healing properties of salmon DNA help repair damaged skin cells, making it a great option for those seeking long-term skin health.

Injected Rejuran: What to Expect

The most common form of Rejuran treatment involves direct injections into the skin. This method delivers PDRN deep into the dermis, where it can stimulate cell regeneration more effectively.

Procedure

• The provider uses a fine needle to inject Rejuran into targeted areas of the face.

• The treatment usually takes 30 to 45 minutes.

• Multiple sessions (typically 3 to 4) spaced 3 to 4 weeks apart are recommended for best results.

  
  

Results

Injected Rejuran can improve skin firmness, reduce fine lines, and smooth out acne scars. Patients often notice gradual improvements over weeks as collagen builds up. The skin becomes more resilient and hydrated, contributing to the sought-after glass skin effect.

Downtime

Downtime is minimal but may include slight redness, swelling, or bruising at injection sites. These effects usually resolve within a few days.

Topical Rejuran Combined with Microneedling and Lasers

An alternative to injections is applying Rejuran topically during other skin treatments like Microneedling or laser therapies such as Morpheus8 and LaseMD Ultra. This approach enhances the absorption of PDRN and boosts skin rejuvenation.

How It Works

• Microneedling creates tiny channels in the skin, allowing topical Rejuran to penetrate deeper.

• Morpheus8 combines Microneedling with radiofrequency (RF) energy to stimulate collagen and tighten skin.

• LaseMD Ultra uses fractional laser technology to resurface skin gently while enhancing product absorption.

  
  

Applying Rejuran topically during these treatments supports healing and accelerates skin repair.

Benefits

• Enhanced collagen production and skin tightening

• Reduced redness and inflammation after laser or Microneedling

• Improved skin texture and tone

• Minimal discomfort and downtime

  
  

Ideal Candidates

This method suits those who prefer less invasive options or want to combine Rejuran with other treatments for comprehensive skin rejuvenation.

Comparing Injected vs. Topical Rejuran

Feature	Injected Rejuran	Topical Rejuran (with Microneedling)
Delivery Method	Micro-injections into the dermis	Applied to skin and absorbed through Microneedling channels
Depth of Penetration	Deep dermal	Superficial to mid-dermal
Performed By	Licensed Nurse Practitioner	Esthetician or Nurse Practitioner
Primary Purpose	Cellular repair and regeneration	Skin quality enhancement
Best For	Thinning, aging, compromised skin	Texture, pores, overall glow
Results Intensity	More intensive and corrective	Subtle, gradual improvement
Downtime	Mild swelling or bumps (1–3 days)	Minimal redness (1–2 days)
Ideal Candidate	Those needing deeper repair	Those wanting enhanced Microneedling and laser results

Why Rejuran Fits into Korean Skincare and Glass Skin Trends

Rejuran aligns perfectly with the principles of Korean skincare, which emphasizes skin health, hydration, and natural glow. The treatment supports the glass skin trend by improving skin clarity, smoothness, and luminosity without heavy makeup or filters.

The viral popularity of Rejuran PDRN treatments reflects growing demand for effective, science-backed solutions that deliver real skin improvements.